Colitis Interuptuses GDC-0032

GDC-0032 is in a new class of cancer treatment drugs know as “targeted therapy”. The name refers to the fact that these drugs primarily focus on cancer cells, leaving healthy cells alone. For over 6 months, Lisa has been on a phase I clinical trial of GDC-0032 and it has kept her disease from progressing. One of the potential side effects of GDC-0032 is inflammation of the colon (colitis). Unfortunately for Lisa, this potential has become a reality.

Signs of colitis first appeared about three weeks ago and she was taken off the drug at that time. Since then, her abdominal pain and nausea has continued to worsen. Yesterday, she was admitted to MGH in order to get the situation under control. Thanks to pain meds and IV fluids she is resting much more comfortably. They have her on a no-food diet in order to rest her bowels.

As I write this, we are waiting for the specialist to show up and let us know what they have planed for her today.

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11 Responses to Colitis Interuptuses GDC-0032

  1. Thanks for the update, Scott. What a journey. Hang in there!
    -Allen

  2. Steve Lewers says:

    Sio/Lisa, Scott tipped me off about this earlier today. Colitis is a real drag..I know. I’m thinking of you and sending good vibes down MGH way. The jungle-like weather up here has abated a bit, so come home fast to enjoy it!

    Steve L.

  3. You and Siobhan are constantly in our thoughts. Brenda and I wish the best of outcomes. We miss seeing you more often!

  4. Elizabeth says:

    Scott and Sioban, So sorry to hear the news. Hoping for a speedy return home. Elizabeth

  5. sara says:

    sending a big hug from Wilton – thinking of you all often and sorry to hear about this setback…hurry home Siobhan!

  6. Deanne Rose says:

    We love you guys and will keep you in our thoughts..hoping she is able to eat food again soon,that is just terrible

  7. Jackie says:

    Scott & Lisa,
    Nasty bump in the road….sorry it’s there. You are always in my prayers and thoughts.
    Hugs,
    Jackie

  8. Maureen Meehan says:

    Lisa, sorry to hear about your hiccup,
    always thinking of you and pray for you everyday.
    Love Maureen

  9. Cathy Baglio says:

    Thanks so much for the update! Please let us know what you find out. Love, Cathy

    Sent from my iPad

  10. Lana Holliday says:

    Our prayers and good wishes are with you. You are strong, Siobhan, and I know you’ll pull through. Always thinking of you, Scott, and the twins.

    Love,

    Lana, David, and Grant

  11. Bob Anderson says:

    You all are in our prayers. Hang in there Lisa.

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