Good-bye T-DM1, Hello GDC-0032

Seasons change and so do cancer treatments. Lisa had a good run with T-DM1, a total of nine treatments over a six-month period, but the time has come for a change.

Thanksgiving 2012

Thanksgiving 2012

T-DM1* worked well for Lisa, however, her CT scans from last Wednesday showed disease progression. With your fingers you can feel that the parotid gland tumors have increased in size and become more defined. The CT scans show that they have increased by about 30% and other lymph node tumors show similar increases. The disease has obviously become resistant to T-DM1, so it’s time for something new and different.

And that something new and different will most likely be GDC-0032; another miracle drug from the wizards at Genetech who brought us T-DM1. GDC-0032 inhibits the PIK3** protein which promotes cancer cell growth. You can think of GDC-0032 as a roadblock on the pathway that signals the cancer cell to grow.

GDC-0032 is so new that it is still in Phase I clinical trials. To receive this treatment, Lisa will enroll in the Phase I trial being conducted at MGH. However, before she can receive her first treatment, she needs to be released from St. Joseph Hospital in Nashua.

Lisa is currently in-patient at St Joseph receiving fluids and medication because she has been unable to keep anything down for the last three days. The exact problem is still unclear, but it is similar to the ileus problem she had back in March. She was looking and feeling much better when I left the hospital this evening and hopefully she will be coming home tomorrow.

* Due to the positive T-DM1 trial results the FDA is giving the drug a “priority-review” with a decision due on Feb. 26, 2012.
**gobbledygook protein… ok, its really the phosphatidylinositol-3 kinase protein
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This entry was posted in GCD-0032, T-DM1 & Systemic Treatment, Uncategorized. Bookmark the permalink.

5 Responses to Good-bye T-DM1, Hello GDC-0032

  1. Thanks for the update Scott. You are all in my prayers.

  2. Pam Kedderis says:

    Thank you for keeping us updated. Hoping and praying.

  3. I know you’re dissappointed as are we. We wish for you to be on the road to eradication! I only wish that there were a healer for you because the world needs one for deserving families like yours. You are in our thoughts and prayers.

  4. Jacqueline Dubiel says:

    Dear Lisa and Scott, Thanks for the update, you’ve been on my mind lately. Glad things have progressed so well for you, and sorry to hear you’re not finished with this devil yet….maybe this new drug will do it. I’ll keep you in my prayers as always. Please give each other hugs for me.

    Love, Jackie

  5. Steve Lewers says:

    Sio and Scott, sounds like another rough patch. If there is anything I can do..no matter at what time or whatever, please call on me. I’ll be thinking of you four and thinking positive thoughts about GDC-0032. Steve Lewers

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